PhD Student (f/m/x) – Frezza Lab at CECAD (KHS-35651)

Your tasks

• Use cell lines and mouse models to investigate the causal link between mitochondrial dysfunction and the pathophysiology of cancer.
• Use molecular biology, biochemistry, and computational techniques to investigate metabolism at the molecular level.
• Perform multi-omics analyses (metabolic, proteomic and transcriptomic studies) and integrate these datasets to generate new hypotheses.
• To accurately record and judiciously analyse, present, and report experimental data.
• Drive your own research project under the supervision of the PI.
• Interact and train junior members and technicians in the lab.

The project of the successful candidate will be part of the CRC1218 on ?Mitochondrial regulation of cellular function?. The candidate will work specifically on the link between mitochondrial ultrastructure and the innate immune response.

Your Profile

• MSc in biology, biochemistry, molecular biology, or equivalent
• Strong expertise in cellular metabolism is a plus
• Proficiency in research procedures and statistical methods
• Effective team player
• Research background in cancer biology, immunology, and/or metabolism is preferred
• Excellent communication skills in written and spoken English
• Demonstrated curiosity-driven science and problem-solving abilities

Our Offer

• Exciting research project in the framework of the mitochondrial research consortium CRC1218
• Supportive and cooperative working environment
• Access to internal and external training programs and inclusion in the research training group of the consortium
• Flexible working hours to accomodate family life
• Occupational health management programs

Your future with us

Working at the University Hospital Cologne and the Medical Faculty means helping to shape the future - the future of medicine, of patients and, of course, your own future. You benefit from 60 clinics and institutes as well as numerous other departments and facilities and more than 12,000 jobs. The Faculty of Medicine of the University of Cologne and the University Hospital Cologne assume important social tasks in research, teaching and patient care. A close network with many university and non-university partners guarantees an internationally successful science and the excellent education of our students.

Your future in detail

CECAD is an inclusive, equal opportunity employer that offers attractive conditions and benefits commensurate with an international research organization with a very collegial and family-friendly work environment.

The Frezza laboratory seeks to understand the contribution of dysregulated metabolism to ageing-associated disorders, focusing on cancer. A part of the lab is investigating how the loss of the mitochondrial enzyme and tumour suppressor Fumarate Hydratase causes renal cancer. Our work has multiple implications: (1) it will provide a mechanistic understanding of the role of metabolism and small molecule metabolites in human diseases; (2) it will generate experimental and computation tools to identify metabolic vulnerabilities that we can use as pharmacological targets for cancer therapy; (3) it will apply metabolomics and multi-omics analyses, to mouse and human models to identify metabolic markers of disease initiation for clinical application in early detection and for patient stratification.

Contact:Prof. Dr. Christian Frezza or Dr. Desiree Schatton
Christian.Frezza@uni-koeln.de or Desiree.Schatton@uk-koeln.de

Application deadline: 18.08.2024

Postal address:Universitätsklinikum Köln AöR
PA29
Geschäftsbereich Personal
50937 Köln